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Science 16 August 1991:
Vol. 253. no. 5021, pp. 789 - 792
DOI: 10.1126/science.1876836
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Articles

Science, Vol 253, Issue 5021, 789-792
Copyright © 1991 by American Association for the Advancement of Science

articles

Identification of Ets- and notch-related subunits in GA binding protein

K LaMarco, CC Thompson, BP Byers, EM Walton, and SL McKnight

Howard Hughes Research Laboratories, Carnegie Institution of Washington, Department of Embryology, Baltimore, MD 21210.

Recombinant cDNA clones that encode two distinct subunits of the transcription factor GA binding protein (GABP) have been isolated. The predicted amino acid sequence of one subunit, GABP alpha, exhibits similarity to the sequence of the product of the ets-1 protooncogene in a region known to encompass the Ets DNA binding domain. The sequence of the second subunit, GABP beta, contains four 33-amino acid repeats located close to the NH2-terminus of the subunit. The sequences of these repeats are similar to repeats in several transmembrane proteins, including Notch from Drosophila melanogaster and Glp-1 and Lin-12 from Caenorhabditis elegans. Avid, sequence-specific binding to DNA required the presence of both polypeptides, revealing a conceptual convergence of nuclear transforming proteins and membrane-anchored proteins implicated in developmentally regulated signal transduction processes.


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The Structure of GABPalpha /beta : An ETS Domain- Ankyrin Repeat Heterodimer Bound to DNA.
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Y Zou, S Evans, J Chen, H. Kuo, R. Harvey, and K. Chien (1997)
Development 124, 793-804
   Abstract »    PDF »
Redox Regulation of GA-binding Protein-alpha DNA Binding Activity.
M. E. Martin, Y. Chinenov, M. Yu, T. K. Schmidt, and X.-Y. Yang (1996)
J. Biol. Chem. 271, 25617-25623
   Abstract »    Full Text »    PDF »
Pax-5 (BSAP) recruits Ets proto-oncogene family proteins to form functional ternary complexes on a B-cell-specific promoter..
D Fitzsimmons, W Hodsdon, W Wheat, S M Maira, B Wasylyk, and J Hagman (1996)
Genes & Dev. 10, 2198-2211
   Abstract »    PDF »
Tissue-specific Activity of the gamma c Chain Gene Promoter Depends upon an Ets Binding Site and Is Regulated by GA-binding Protein.
S. Markiewicz, R. Bosselut, F. L. Deist, J.-P. d. Villartay, C. Hivroz, J. Ghysdael, A. Fischer, and G. d. S. Basile (1996)
J. Biol. Chem. 271, 14849-14855
   Abstract »    Full Text »    PDF »
c-sis/PDGF-B Promoter Transactivation by the Tax Protein of Human T-cell Leukemia Virus Type 1.
S. R. Trejo, W. E. Fahl, and L. Ratner (1996)
J. Biol. Chem. 271, 14584-14590
   Abstract »    Full Text »    PDF »
Lipopolysaccharide Induction of THP-1 Cells Activates Binding of c-Jun, Ets, and Egr-1 to the Tissue Factor Promoter.
E. R. Groupp and M. Donovan-Peluso (1996)
J. Biol. Chem. 271, 12423-12430
   Abstract »    Full Text »    PDF »
Molecular Cloning and Characterization of a Novel Human Diacylglycerol Kinase [IMAGE].
M. Bunting, W. Tang, G. A. Zimmerman, T. M. McIntyre, and S. M. Prescott (1996)
J. Biol. Chem. 271, 10230-10236
   Abstract »    Full Text »    PDF »
Transcriptional Regulation of the Genes Involved in Lipoprotein Transport : The Role of Proximal Promoters and Long-range Regulatory Elements and Factors in Apolipoprotein Gene Regulation.
D. Kardassis, M. Laccotripe, I. Talianidis, and V. Zannis (1996)
Hypertension 27, 980-1008
   Full Text »
The GA-binding Protein Can Serve as Both an Activator and Repressor of ribosomal protein Gene Transcription.
R. R. Genuario and R. P. Perry (1996)
J. Biol. Chem. 271, 4388-4395
   Abstract »    Full Text »    PDF »
GABP and PU.1 Compete for Binding, yet Cooperate to Increase CD18 (beta(2) Leukocyte Integrin) Transcription.
A. G. Rosmarin, D. G. Caprio, D. G. Kirsch, H. Handa, and C. P. Simkevich (1995)
J. Biol. Chem. 270, 23627-23633
   Abstract »    Full Text »    PDF »
ERM, a PEA3 Subfamily of Ets Transcription Factors, Can Cooperate with c-Jun.
K. Nakae, K. Nakajima, J. Inazawa, T. Kitaoka, and T. Hirano (1995)
J. Biol. Chem. 270, 23795-23800
   Abstract »    Full Text »    PDF »
Modulation of transcription factor Ets-1 DNA binding: DNA-induced unfolding of an alpha helix.
J. Petersen, J. Skalicky, L. Donaldson, L. McIntosh, T Alber, and B. Graves (1995)
Science 269, 1866-1869
   Abstract »    PDF »
The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes.
C. Schoenherr and D. Anderson (1995)
Science 267, 1360-1363
   Abstract »    PDF »
The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD.
R. Kopan, J. S. Nye, and H. Weintraub (1994)
Development 120, 2385-2396
   Abstract »    PDF »
Molecular and genetic characterization of GABP beta..
F C de la Brousse, E H Birkenmeier, D S King, L B Rowe, and S L McKnight (1994)
Genes & Dev. 8, 1853-1865
   Abstract »    PDF »
Cytosolic interaction between deltex and Notch ankyrin repeats implicates deltex in the Notch signaling pathway.
R. Diederich, K Matsuno, H Hing, and S Artavanis-Tsakonas (1994)
Development 120, 473-481
   Abstract »    PDF »
Identity of GABP with NRF-2, a multisubunit activator of cytochrome oxidase expression, reveals a cellular role for an ETS domain activator of viral promoters..
J V Virbasius, C A Virbasius, and R C Scarpulla (1993)
Genes & Dev. 7, 380-392
   Abstract »    PDF »
The Drosophila gene pointed encodes two ETS-like proteins which are involved in the development of the midline glial cells.
C. Klambt (1993)
Development 117, 163-176
   Abstract »    PDF »
Notch2: a second mammalian Notch gene.
G. Weinmaster, V. J. Roberts, and G. Lemke (1992)
Development 116, 931-941
   Abstract »    PDF »
The proto-oncogene bcl-3 encodes an I kappa B protein..
L D Kerr, C S Duckett, P Wamsley, Q Zhang, P Chiao, G Nabel, T W McKeithan, P A Baeuerle, and I M Verma (1992)
Genes & Dev. 6, 2352-2363
   Abstract »    PDF »
Specificities of protein-protein and protein-DNA interaction of GABP alpha and two newly defined ets-related proteins..
T A Brown and S L McKnight (1992)
Genes & Dev. 6, 2502-2512
   Abstract »    PDF »
A novel modulator domain of Ets transcription factors..
C Wasylyk, J P Kerckaert, and B Wasylyk (1992)
Genes & Dev. 6, 965-974
   Abstract »    PDF »
Interaction of murine ets-1 with GGA-binding sites establishes the ETS domain as a new DNA-binding motif..
J A Nye, J M Petersen, C V Gunther, M D Jonsen, and B J Graves (1992)
Genes & Dev. 6, 975-990
   Abstract »    PDF »
Cloning and expression in yeast of a plant potassium ion transport system.
H Sentenac, N Bonneaud, M Minet, F Lacroute, J. Salmon, F Gaymard, and C Grignon (1992)
Science 256, 663-665
   Abstract »    PDF »
Expression of an activated Notch-related int-3 transgene interferes with cell differentiation and induces neoplastic transformation in mammary and salivary glands..
C Jhappan, D Gallahan, C Stahle, E Chu, G H Smith, G Merlino, and R Callahan (1992)
Genes & Dev. 6, 345-355
   Abstract »    PDF »
Molecular cloning and characterization of PEA3, a new member of the Ets oncogene family that is differentially expressed in mouse embryonic cells..
J H Xin, A Cowie, P Lachance, and J A Hassell (1992)
Genes & Dev. 6, 481-496
   Abstract »    PDF »
Regulation of Induction by GLP1, a Localized Cell Surface Receptor in Caenorhabditis elegans.
J. Kimble, S. Crittenden, E. Lambie, V. Kodoyianni, S. Mango, and E. Troemel (1992)
Cold Spring Harb Symp Quant Biol 57, 401-407
   Abstract »    PDF »
Convergence of Ets- and notch-related structural motifs in a heteromeric DNA binding complex.
C. Thompson, T. Brown, and S. McKnight (1991)
Science 253, 762-768
   Abstract »    PDF »
Identification of Amino Acid Residues in the ETS Transcription Factor Erg That Mediate Erg-Jun/Fos-DNA Ternary Complex Formation.
A. Verger, E. Buisine, S. Carrere, R. Wintjens, A. Flourens, J. Coll, D. Stehelin, and M. Duterque-Coquillaud (2001)
J. Biol. Chem. 276, 17181-17189
   Abstract »    Full Text »    PDF »


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