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Science 22 November 1991:
Vol. 254. no. 5035, pp. 1178 - 1181
DOI: 10.1126/science.1957169

Articles

Science, Vol 254, Issue 5035, 1178-1181
Copyright © 1991 by American Association for the Advancement of Science


articles

Optical coherence tomography

D Huang, EA Swanson, CP Lin, JS Schuman, WG Stinson, W Chang, MR Hee, T Flotte, K Gregory, CA Puliafito, and al. et

Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge 02139.

A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as approximately 10(-10) of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.


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   Abstract »    Full Text »    PDF »
Optical Coherence Tomography and Histologic Measurements of Nerve Fiber Layer Thickness in Normal and Glaucomatous Monkey Eyes.
J. S. Schuman, T. Pedut-Kloizman, H. Pakter, N. Wang, V. Guedes, L. Huang, L. Pieroth, W. Scott, M. R. Hee, J. G. Fujimoto, et al. (2007)
Invest. Ophthalmol. Vis. Sci. 48, 3645-3654
   Abstract »    Full Text »    PDF »
Reproducibility of Anterior Chamber Angle Measurements Obtained with Anterior Segment Optical Coherence Tomography.
S. Radhakrishnan, J. See, S. D. Smith, W. P. Nolan, Z. Ce, D. S. Friedman, D. Huang, Y. Li, T. Aung, and P. T. K. Chew (2007)
Invest. Ophthalmol. Vis. Sci. 48, 3683-3688
   Abstract »    Full Text »    PDF »
Optic nerve magnetization transfer imaging and measures of axonal loss and demyelination in optic neuritis.
S. Trip, P. Schlottmann, S. Jones, W-Y. Li, D. Garway-Heath, A. Thompson, G. Plant, and D. Miller (2007)
Multiple Sclerosis 13, 875-879
   Abstract »    PDF »
Nondestructive Quantification of Analyte Diffusion in Cornea and Sclera Using Optical Coherence Tomography.
M. G. Ghosn, V. V. Tuchin, and K. V. Larin (2007)
Invest. Ophthalmol. Vis. Sci. 48, 2726-2733
   Abstract »    Full Text »    PDF »
Intrinsic Signal Imaging in Macaque Retina Reveals Different Types of Flash-Induced Light Reflectance Changes of Different Origins.
G. Hanazono, K. Tsunoda, K. Shinoda, K. Tsubota, Y. Miyake, and M. Tanifuji (2007)
Invest. Ophthalmol. Vis. Sci. 48, 2903-2912
   Abstract »    Full Text »    PDF »
High-Speed Ultra-High-Resolution Optical Coherence Tomography Findings in Hydroxychloroquine Retinopathy.
J. A. Rodriguez-Padilla, T. R. Hedges III, B. Monson, V. Srinivasan, M. Wojtkowski, E. Reichel, J. S. Duker, J. S. Schuman, and J. G. Fujimoto (2007)
Arch Ophthalmol 125, 775-780
   Abstract »    Full Text »    PDF »
Optical coherence tomography can monitor reversible nerve-fibre layer changes in a patient with ethambutol-induced optic neuropathy.
C. I Zoumalan and A. A Sadun (2007)
Br J Ophthalmol 91, 839-840
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Optical Coherence Tomography of the Macula in Congenital Achromatopsia.
B. Varsanyi, G. M. Somfai, B. Lesch, R. Vamos, and A. Farkas (2007)
Invest. Ophthalmol. Vis. Sci. 48, 2249-2253
   Abstract »    Full Text »    PDF »
Retinal Abnormalities in Early Alzheimer's Disease.
F. Berisha, G. T. Feke, C. L. Trempe, J. W. McMeel, and C. L. Schepens (2007)
Invest. Ophthalmol. Vis. Sci. 48, 2285-2289
   Abstract »    Full Text »    PDF »



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