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Science 12 July 1996:
Vol. 273. no. 5272, pp. 236 - 238
DOI: 10.1126/science.273.5272.236
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Reports

Polar Overdominance at the Ovine callipyge Locus

Noelle E. Cockett, Sam P. Jackson, Tracy L. Shay, Frédéric Farnir, Stéphane Berghmans, Gary D. Snowder, Dahlia M. Nielsen, Michel Georges *

An inheritable muscular hypertrophy was recently described in sheep and shown to be determined by the callipyge gene mapped to ovine chromosome 18. Here, the callipyge phenotype was found to be characterized by a nonmendelian inheritance pattern, referred to as polar overdominance, where only heterozygous individuals having inherited the callipyge mutation from their sire express the phenotype. The possible role of parental imprinting in the determinism of polar overdominance is envisaged.

N. E. Cockett, T. L. Shay, D. M. Nielsen, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT 84322-4700, USA.
S. P. Jackson, Department of Animal Science and Food Technology, Texas Tech University, Lubbock, TX 79409, USA.
F. Farnir, S. Berghmans, M. Georges, Department of Genetics, Faculty of Veterinary Medicine, University of Liège (B43), 20 Bd de Colonster, 4000-Liège, Belgium.
G. D. Snowder, Agricultural Research Service, U.S. Department of Agriculture, U.S. Sheep Experiment Station, Dubois, ID 83423, USA.
* To whom correspondence should be addressed.


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