Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 15 August 1997:
Vol. 277. no. 5328, pp. 942 - 946
DOI: 10.1126/science.277.5328.942
Prev | Table of Contents | Next

Reports

daf-2, an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans

Koutarou D. Kimura, * Heidi A. Tissenbaum, * Yanxia Liu, Gary Ruvkun dagger

A C. elegans neurosecretory signaling system regulates whether animals enter the reproductive life cycle or arrest development at the long-lived dauer diapause stage. daf-2, a key gene in the genetic pathway that mediates this endocrine signaling, encodes an insulin receptor family member. Decreases in DAF-2 signaling induce metabolic and developmental changes, as in mammalian metabolic control by the insulin receptor. Decreased DAF-2 signaling also causes an increase in life-span. Life-span regulation by insulin-like metabolic control is analogous to mammalian longevity enhancement induced by caloric restriction, suggesting a general link between metabolism, diapause, and longevity.

Department of Molecular Biology, Massachusetts General Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02114, USA.
*   These authors contributed equally to this report.

dagger    To whom correspondence should be addressed. E-mail: ruvkun{at}opal.mgh.harvard.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The endosymbiont Wolbachia increases insulin/IGF-like signalling in Drosophila.
T. Ikeya, S. Broughton, N. Alic, R. Grandison, and L. Partridge (2009)
Proc R Soc B 276, 3799-3807
   Abstract »    Full Text »    PDF »
C. elegans as Model for the Study of High Glucose- Mediated Life Span Reduction.
A. Schlotterer, G. Kukudov, F. Bozorgmehr, H. Hutter, X. Du, D. Oikonomou, Y. Ibrahim, F. Pfisterer, N. Rabbani, P. Thornalley, et al. (2009)
Diabetes 58, 2450-2456
   Abstract »    Full Text »    PDF »
Loss of the apical V-ATPase a-subunit VHA-6 prevents acidification of the intestinal lumen during a rhythmic behavior in C. elegans.
E. Allman, D. Johnson, and K. Nehrke (2009)
Am J Physiol Cell Physiol 297, C1071-C1081
   Abstract »    Full Text »    PDF »
New Insights Into Cardiac Aging.
A. J. Muslin (2009)
Circulation 120, 1654-1656
   Full Text »    PDF »
Insulin Receptor Isoforms and Insulin Receptor/Insulin-Like Growth Factor Receptor Hybrids in Physiology and Disease.
A. Belfiore, F. Frasca, G. Pandini, L. Sciacca, and R. Vigneri (2009)
Endocr. Rev. 30, 586-623
   Abstract »    Full Text »    PDF »
Neuronal IGF-1 resistance reduces A{beta} accumulation and protects against premature death in a model of Alzheimer's disease.
S. Freude, M. M. Hettich, C. Schumann, O. Stohr, L. Koch, C. Kohler, M. Udelhoven, U. Leeser, M. Muller, N. Kubota, et al. (2009)
FASEB J 23, 3315-3324
   Abstract »    Full Text »    PDF »
Stimulation of Movement in a Quiescent, Hibernation-Like Form of Caenorhabditis elegans by Dopamine Signaling.
M. M. Gaglia and C. Kenyon (2009)
J. Neurosci. 29, 7302-7314
   Abstract »    Full Text »    PDF »
Lifespan extension by suppression of autophagy genes in Caenorhabditis elegans.
Y. Hashimoto, S. Ookuma, and E. Nishida (2009)
Genes Cells 14, 717-726
   Abstract »    Full Text »    PDF »
Proteasomal Regulation of the Hypoxic Response Modulates Aging in C. elegans.
R. Mehta, K. A. Steinkraus, G. L. Sutphin, F. J. Ramos, L. S. Shamieh, A. Huh, C. Davis, D. Chandler-Brown, and M. Kaeberlein (2009)
Science 324, 1196-1198
   Abstract »    Full Text »    PDF »
Caenorhabditis elegans as an emerging model for studying the basic biology of obesity.
K. T. Jones and K. Ashrafi (2009)
Dis. Model. Mech. 2, 224-229
   Abstract »    Full Text »    PDF »
Functional interactions between the ciliopathy-associated Meckel syndrome 1 (MKS1) protein and two novel MKS1-related (MKSR) proteins.
N. J. Bialas, P. N. Inglis, C. Li, J. F. Robinson, J. D. K. Parker, M. P. Healey, E. E. Davis, C. D. Inglis, T. Toivonen, D. C. Cottell, et al. (2009)
J. Cell Sci. 122, 611-624
   Abstract »    Full Text »    PDF »
Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans.
A. A. Soukas, E. A. Kane, C. E. Carr, J. A. Melo, and G. Ruvkun (2009)
Genes & Dev. 23, 496-511
   Abstract »    Full Text »    PDF »
Biosynthesis of the Caenorhabditis elegans dauer pheromone.
R. A. Butcher, J. R. Ragains, W. Li, G. Ruvkun, J. Clardy, and H. Y. Mak (2009)
PNAS 106, 1875-1879
   Abstract »    Full Text »    PDF »
The conserved NAD(H)-dependent corepressor CTBP-1 regulates Caenorhabditis elegans life span.
S. Chen, J. R. Whetstine, S. Ghosh, J. A. Hanover, R. R. Gali, P. Grosu, and Y. Shi (2009)
PNAS 106, 1496-1501
   Abstract »    Full Text »    PDF »
Inhibition of a eukaryotic initiation factor (eIF2B{delta}/F11A3.2) during adulthood extends lifespan in Caenorhabditis elegans.
D. Tohyama, A. Yamaguchi, and T. Yamashita (2008)
FASEB J 22, 4327-4337
   Abstract »    Full Text »    PDF »
How to Live Long and Prosper: Autophagy, Mitochondria, and Aging.
W.-L. Yen and D. J. Klionsky (2008)
Physiology 23, 248-262
   Abstract »    Full Text »    PDF »
Use of shotgun proteomics for the identification, confirmation, and correction of C. elegans gene annotations.
G. E. Merrihew, C. Davis, B. Ewing, G. Williams, L. Kall, B. E. Frewen, W. S. Noble, P. Green, J. H. Thomas, and M. J. MacCoss (2008)
Genome Res. 18, 1660-1669
   Abstract »    Full Text »    PDF »
glo-3, a Novel Caenorhabditis elegans Gene, Is Required for Lysosome-Related Organelle Biogenesis.
B. M. Rabbitts, M. K. Ciotti, N. E. Miller, M. Kramer, A. L. Lawrenson, S. Levitte, S. Kremer, E. Kwan, A. M. Weis, and G. J. Hermann (2008)
Genetics 180, 857-871
   Abstract »    Full Text »    PDF »
A potent dauer pheromone component in Caenorhabditis elegans that acts synergistically with other components.
R. A. Butcher, J. R. Ragains, E. Kim, and J. Clardy (2008)
PNAS 105, 14288-14292
   Abstract »    Full Text »    PDF »
C. elegans dauer formation and the molecular basis of plasticity.
N. Fielenbach and A. Antebi (2008)
Genes & Dev. 22, 2149-2165
   Abstract »    Full Text »    PDF »
Protein-Repair and Hormone-Signaling Pathways Specify Dauer and Adult Longevity and Dauer Development in Caenorhabditis elegans.
K. L. Banfield, T. A. Gomez, W. Lee, S. Clarke, and P. L. Larsen (2008)
J. Gerontol. A Biol. Sci. Med. Sci. 63, 798-808
   Abstract »    Full Text »    PDF »
A branched-chain fatty acid is involved in post-embryonic growth control in parallel to the insulin receptor pathway and its biosynthesis is feedback-regulated in C. elegans.
M. Kniazeva, T. Euler, and M. Han (2008)
Genes & Dev. 22, 2102-2110
   Abstract »    Full Text »    PDF »
Acute carbon dioxide avoidance in Caenorhabditis elegans.
E. A. Hallem and P. W. Sternberg (2008)
PNAS 105, 8038-8043
   Abstract »    Full Text »    PDF »
Discovery of a Cholecystokinin-Gastrin-Like Signaling System in Nematodes.
T. Janssen, E. Meelkop, M. Lindemans, K. Verstraelen, S. J. Husson, L. Temmerman, R. J. Nachman, and L. Schoofs (2008)
Endocrinology 149, 2826-2839
   Abstract »    Full Text »    PDF »
Evolution of the Insulin Receptor Family and Receptor Isoform Expression in Vertebrates.
C. Hernandez-Sanchez, A. Mansilla, F. de Pablo, and R. Zardoya (2008)
Mol. Biol. Evol. 25, 1043-1053
   Abstract »    Full Text »    PDF »
APY-1, a Novel Caenorhabditis elegans Apyrase Involved in Unfolded Protein Response Signalling and Stress Responses.
D. Uccelletti, A. Pascoli, F. Farina, A. Alberti, P. Mancini, C. B. Hirschberg, and C. Palleschi (2008)
Mol. Biol. Cell 19, 1337-1345
   Abstract »    Full Text »    PDF »
Longevity and resistance to stress correlate with DNA repair capacity in Caenorhabditis elegans.
M. Hyun, J. Lee, K. Lee, A. May, V. A. Bohr, and B. Ahn (2008)
Nucleic Acids Res. 36, 1380-1389
   Abstract »    Full Text »    PDF »
Functionally significant insulin-like growth factor I receptor mutations in centenarians.
Y. Suh, G. Atzmon, M.-O. Cho, D. Hwang, B. Liu, D. J. Leahy, N. Barzilai, and P. Cohen (2008)
PNAS 105, 3438-3442
   Abstract »    Full Text »    PDF »
Signaling networks in aging.
E. L. Greer and A. Brunet (2008)
J. Cell Sci. 121, 407-412
   Full Text »    PDF »
Clustering of Genetically Defined Allele Classes in the Caenorhabditis elegans DAF-2 Insulin/IGF-1 Receptor.
D. S. Patel, A. Garza-Garcia, M. Nanji, J. J. McElwee, D. Ackerman, P. C. Driscoll, and D. Gems (2008)
Genetics 178, 931-946
   Abstract »    Full Text »    PDF »
Distinct Activities of the Germline and Somatic Reproductive Tissues in the Regulation of Caenorhabditis elegans' Longevity.
T. M. Yamawaki, N. Arantes-Oliveira, J. R. Berman, P. Zhang, and C. Kenyon (2008)
Genetics 178, 513-526
   Abstract »    Full Text »    PDF »
A Measurable Increase in Oxidative Damage Due to Reduction in Superoxide Detoxification Fails to Shorten the Life Span of Long-Lived Mitochondrial Mutants of Caenorhabditis elegans.
W. Yang, J. Li, and S. Hekimi (2007)
Genetics 177, 2063-2074
   Abstract »    Full Text »    PDF »
Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans.
C. T. Murphy, S.-J. Lee, and C. Kenyon (2007)
PNAS 104, 19046-19050
   Abstract »    Full Text »    PDF »
Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants.
A. V. Samuelson, C. E. Carr, and G. Ruvkun (2007)
Genes & Dev. 21, 2976-2994
   Abstract »    Full Text »    PDF »
2006 Kent Award Lecture: Is Cell Death and Replacement a Factor in Aging?.
H. R. Warner (2007)
J. Gerontol. A Biol. Sci. Med. Sci. 62, 1228-1232
   Abstract »    Full Text »    PDF »
Frequency of the G/G Genotype of Resistin Single Nucleotide Polymorphism at 420 Appears to Be Increased in Younger-Onset Type 2 Diabetes.
M. Ochi, H. Osawa, Y. Hirota, K. Hara, Y. Tabara, Y. Tokuyama, I. Shimizu, A. Kanatsuka, Y. Fujii, J. Ohashi, et al. (2007)
Diabetes 56, 2834-2838
   Abstract »    Full Text »    PDF »
SPD-3 Is Required for Spindle Alignment in Caenorhabditis elegans Embryos and Localizes to Mitochondria.
M. V. Dinkelmann, H. Zhang, A. R. Skop, and J. G. White (2007)
Genetics 177, 1609-1620
   Abstract »    Full Text »    PDF »
Genetic Analysis of Dauer Formation in Caenorhabditis briggsae.
T. Inoue, M. Ailion, S. Poon, H. K. Kim, J. H. Thomas, and P. W. Sternberg (2007)
Genetics 177, 809-818
   Abstract »    Full Text »    PDF »
Gravity Force Transduced by the MEC-4/MEC-10 DEG/ENaC Channel Modulates DAF-16/FoxO Activity in Caenorhabditis elegans.
N. Kim, C. M. Dempsey, C.-J. Kuan, J. V. Zoval, E. O'Rourke, G. Ruvkun, M. J. Madou, and J. Y. Sze (2007)
Genetics 177, 835-845
   Abstract »    Full Text »    PDF »
Monitoring of lipid storage in Caenorhabditis elegans using coherent anti-Stokes Raman scattering (CARS) microscopy.
T. Hellerer, C. Axang, C. Brackmann, P. Hillertz, M. Pilon, and A. Enejder (2007)
PNAS 104, 14658-14663
   Abstract »    Full Text »    PDF »
Quantitative Mass Spectrometry Identifies Insulin Signaling Targets in C. elegans.
M.-Q. Dong, J. D. Venable, N. Au, T. Xu, S. K. Park, D. Cociorva, J. R. Johnson, A. Dillin, and J. R. Yates III (2007)
Science 317, 660-663
   Abstract »    Full Text »    PDF »
Dynamic FoxO transcription factors.
H. Huang and D. J. Tindall (2007)
J. Cell Sci. 120, 2479-2487
   Abstract »    Full Text »    PDF »
If You Wish to Live a Long Time in Good Health, Choose Your Parents Carefully.
H. R. Warner (2007)
J. Gerontol. A Biol. Sci. Med. Sci. 62, 575-576
   Full Text »    PDF »
FOXO Transcription Factors in the Regulatory Networks of Longevity.
H. Daitoku and A. Fukamizu (2007)
J. Biochem. 141, 769-774
   Abstract »    Full Text »    PDF »
Sirt1 Regulates Aging and Resistance to Oxidative Stress in the Heart.
R. R. Alcendor, S. Gao, P. Zhai, D. Zablocki, E. Holle, X. Yu, B. Tian, T. Wagner, S. F. Vatner, and J. Sadoshima (2007)
Circ. Res. 100, 1512-1521
   Abstract »    Full Text »    PDF »
Liver X Receptor Alpha Associates With Human Life Span.
S. P. Mooijaart, M. Kuningas, R. G. J. Westendorp, J. J. Houwing-Duistermaat, P. E. Slagboom, P. C. N. Rensen, and D. van Heemst (2007)
J. Gerontol. A Biol. Sci. Med. Sci. 62, 343-349
   Abstract »    Full Text »    PDF »
The P-type ATPase CATP-1 is a novel regulator of C. elegans developmental timing that acts independently of its predicted pump function.
A.-F. Ruaud and J.-L. Bessereau (2007)
Development 134, 867-879
   Abstract »    Full Text »    PDF »
Inhibition of wild-type p66ShcA in mesangial cells prevents glycooxidant-dependent FOXO3a regulation and promotes the survival phenotype.
J. Chintapalli, S. Yang, D. Opawumi, S. R. Goyal, N. Shamsuddin, A. Malhotra, K. Reiss, and L. G. Meggs (2007)
Am J Physiol Renal Physiol 292, F523-F530
   Abstract »    Full Text »    PDF »
Identification of Caenorhabditis elegans Genes Regulating Longevity Using Enhanced RNAi-sensitive Strains.
A. V. Samuelson, R. R. Klimczak, D. B. Thompson, C. E. Carr, and G. Ruvkun (2007)
Cold Spring Harb Symp Quant Biol 72, 489-497
   Abstract »    PDF »
Insulin-like signaling and the neural circuit for integrative behavior in C. elegans..
E. Kodama, A. Kuhara, A. Mohri-Shiomi, K. D. Kimura, M. Okumura, M. Tomioka, Y. Iino, and I. Mori (2006)
Genes & Dev. 20, 2955-2960
   Abstract »    Full Text »    PDF »
Glyceraldehyde-3-Phosphate Dehydrogenase Mediates Anoxia Response and Survival in Caenorhabditis elegans.
A. R. Mendenhall, B. LaRue, and P. A. Padilla (2006)
Genetics 174, 1173-1187
   Abstract »    Full Text »    PDF »
Opposing Activities Protect Against Age-Onset Proteotoxicity.
E. Cohen, J. Bieschke, R. M. Perciavalle, J. W. Kelly, and A. Dillin (2006)
Science 313, 1604-1610
   Abstract »    Full Text »    PDF »
The neuroendocrine system of invertebrates: a developmental and evolutionary perspective..
V. Hartenstein (2006)
J. Endocrinol. 190, 555-570
   Abstract »    Full Text »    PDF »
Effects of Sex and Insulin/Insulin-Like Growth Factor-1 Signaling on Performance in an Associative Learning Paradigm in Caenorhabditis elegans.
T. Vellai, D. McCulloch, D. Gems, and A. L. Kovacs (2006)
Genetics 174, 309-316
   Abstract »    Full Text »    PDF »
Caenorhabditis elegans ortholog of a diabetes susceptibility locus: oga-1 (O-GlcNAcase) knockout impacts O-GlcNAc cycling, metabolism, and dauer.
M. E. Forsythe, D. C. Love, B. D. Lazarus, E. J. Kim, W. A. Prinz, G. Ashwell, M. W. Krause, and J. A. Hanover (2006)
PNAS 103, 11952-11957
   Abstract »    Full Text »    PDF »
Checkpoint proteins control survival of the postmitotic cells in Caenorhabditis elegans..
A. Olsen, M. C. Vantipalli, and G. J. Lithgow (2006)
Science 312, 1381-1385
   Abstract »    Full Text »    PDF »
daf-16 Protects the Nematode Caenorhabditis elegans During Food Deprivation..
S. T. Henderson, M. Bonafe, and T. E. Johnson (2006)
J. Gerontol. A Biol. Sci. Med. Sci. 61, 444-460
   Abstract »    Full Text »    PDF »
The Adaptor Protein soc-1/Gab1 Modifies Growth Factor Receptor Output in Caenorhabditis elegans.
N. A. Hopper (2006)
Genetics 173, 163-175
   Abstract »    Full Text »    PDF »
A Novel Sulfotransferase Abundantly Expressed in the Dauer Larvae of Caenorhabditis elegans..
K. Hattori, M. Inoue, T. Inoue, H. Arai, and H.-o. Tamura (2006)
J. Biochem. 139, 355-362
   Abstract »    Full Text »    PDF »
Inhibition of germline proliferation during C. elegans dauer development requires PTEN, LKB1 and AMPK signalling.
P. Narbonne and R. Roy (2006)
Development 133, 611-619
   Abstract »    Full Text »    PDF »
Genetics of aging: implications for drug discovery and development.
B. J Geesaman (2006)
Am. J. Clinical Nutrition 83, 466S-469S
   Abstract »    Full Text »    PDF »
Longevity and ageing: appraising the evolutionary consequences of growing old.
M. B Bonsall (2006)
Phil Trans R Soc B 361, 119-135
   Abstract »    Full Text »    PDF »
Extension of chronological life span in yeast by decreased TOR pathway signaling.
R. W. Powers III, M. Kaeberlein, S. D. Caldwell, B. K. Kennedy, and S. Fields (2006)
Genes & Dev. 20, 174-184
   Abstract »    Full Text »    PDF »
Oxidative stress and ageing: is ageing a cysteine deficiency syndrome?.
W. Droge (2005)
Phil Trans R Soc B 360, 2355-2372
   Abstract »    Full Text »    PDF »
A Developmental Timing MicroRNA and Its Target Regulate Life Span in C. elegans.
M. Boehm and F. Slack (2005)
Science 310, 1954-1957
   Abstract »    Full Text »    PDF »
The Caenorhabditis elegans Heterochronic Regulator LIN-14 Is a Novel Transcription Factor That Controls the Developmental Timing of Transcription from the Insulin/Insulin-Like Growth Factor Gene ins-33 by Direct DNA Binding.
M. Hristova, D. Birse, Y. Hong, and V. Ambros (2005)
Mol. Cell. Biol. 25, 11059-11072
   Abstract »    Full Text »    PDF »
Aging-Dependent and -Independent Modulation of Associative Learning Behavior by Insulin/Insulin-Like Growth Factor-1 Signal in Caenorhabditis elegans.
H. Murakami, K. Bessinger, J. Hellmann, and S. Murakami (2005)
J. Neurosci. 25, 10894-10904
   Abstract »    Full Text »    PDF »
Developing a Research Agenda in Biogerontology: Basic Mechanisms.
H. R. Warner (2005)
Sci. Aging Knowl. Environ. 2005, pe33
   Abstract »    Full Text »
Oxidative Aging and Insulin Receptor Signaling.
W. Droge (2005)
J. Gerontol. A Biol. Sci. Med. Sci. 60, 1378-1385
   Abstract »    Full Text »    PDF »
Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice.
X. Liu, N. Jiang, B. Hughes, E. Bigras, E. Shoubridge, and S. Hekimi (2005)
Genes & Dev. 19, 2424-2434
   Abstract »    Full Text »    PDF »
cDNA structure of an insulin-related peptide in the Pacific oyster and seasonal changes in the gene expression.
K Hamano, M Awaji, and H Usuki (2005)
J. Endocrinol. 187, 55-67
   Abstract »    Full Text »    PDF »
A Caenorhabditis elegans model of insulin resistance: Altered macronutrient storage and dauer formation in an OGT-1 knockout.
J. A. Hanover, M. E. Forsythe, P. T. Hennessey, T. M. Brodigan, D. C. Love, G. Ashwell, and M. Krause (2005)
PNAS 102, 11266-11271
   Abstract »    Full Text »    PDF »
Multidrug resistance-associated protein MRP-1 regulates dauer diapause by its export activity in Caenorhabditis elegans.
T. Yabe, N. Suzuki, T. Furukawa, T. Ishihara, and I. Katsura (2005)
Development 132, 3197-3207
   Abstract »    Full Text »    PDF »
A systematic RNAi screen for longevity genes in C. elegans.
B. Hamilton, Y. Dong, M. Shindo, W. Liu, I. Odell, G. Ruvkun, and S. S. Lee (2005)
Genes & Dev. 19, 1544-1555
   Abstract »    Full Text »    PDF »
Genes, Phenes, and Dreams of Immortality: The 2003 Kleemeier Award Lecture.
T. E. Johnson (2005)
J. Gerontol. A Biol. Sci. Med. Sci. 60, 680-687
   Abstract »    Full Text »    PDF »
Counting the Calories: The Role of Specific Nutrients in Extension of Life Span by Food Restriction.
M. D. W. Piper, W. Mair, and L. Partridge (2005)
J. Gerontol. A Biol. Sci. Med. Sci. 60, 549-555
   Abstract »    Full Text »    PDF »
Insulin Signaling in the Central Nervous System: A Critical Role in Metabolic Homeostasis and Disease From C. elegans to Humans.
D. Porte Jr., D. G. Baskin, and M. W. Schwartz (2005)
Diabetes 54, 1264-1276
   Abstract »    Full Text »    PDF »
Analysis of long-lived C. elegans daf-2 mutants using serial analysis of gene expression.
J. Halaschek-Wiener, J. S. Khattra, S. McKay, A. Pouzyrev, J. M. Stott, G. S. Yang, R. A. Holt, S. J.M. Jones, M. A. Marra, A. R. Brooks-Wilson, et al. (2005)
Genome Res. 15, 603-615
   Abstract »    Full Text »    PDF »
Estrogen, Insulin, and Dietary Signals Cooperatively Regulate Longevity Signals to Enhance Resistance to Oxidative Stress in Mice.
T. Baba, T. Shimizu, Y.-i. Suzuki, M. Ogawara, K.-i. Isono, H. Koseki, H. Kurosawa, and T. Shirasawa (2005)
J. Biol. Chem. 280, 16417-16426
   Abstract »    Full Text »    PDF »
JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16.
S. W. Oh, A. Mukhopadhyay, N. Svrzikapa, F. Jiang, R. J. Davis, and H. A. Tissenbaum (2005)
PNAS 102, 4494-4499
   Abstract »    Full Text »    PDF »
Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands.
S. J. Broughton, M. D. W. Piper, T. Ikeya, T. M. Bass, J. Jacobson, Y. Driege, P. Martinez, E. Hafen, D. J. Withers, S. J. Leevers, et al. (2005)
PNAS 102, 3105-3110
   Abstract »    Full Text »    PDF »
Transcriptional targets of DAF-16 insulin signaling pathway protect C. elegans from extreme hypertonic stress.
S. T. Lamitina and K. Strange (2005)
Am J Physiol Cell Physiol 288, C467-C474
   Abstract »    Full Text »    PDF »
DNA Methyltransferase Gene dDnmt2 and Longevity of Drosophila.
M.-J. Lin, L.-Y. Tang, M. N. Reddy, and C.-K. J. Shen (2005)
J. Biol. Chem. 280, 861-864
   Abstract »    Full Text »    PDF »
Behavioral Deficits During Early Stages of Aging in Caenorhabditis elegans Result From Locomotory Deficits Possibly Linked to Muscle Frailty.
C. F. Glenn, D. K. Chow, L. David, C. A. Cooke, M. S. Gami, W. B. Iser, K. B. Hanselman, I. G. Goldberg, and C. A. Wolkow (2004)
J. Gerontol. A Biol. Sci. Med. Sci. 59, 1251-1260
   Abstract »    Full Text »    PDF »
NCR-1 and NCR-2, the C. elegans homologs of the human Niemann-Pick type C1 disease protein, function upstream of DAF-9 in the dauer formation pathways.
J. Li, G. Brown, M. Ailion, S. Lee, and J. H. Thomas (2004)
Development 131, 5741-5752
   Abstract »    Full Text »    PDF »
Sirviving Cardiac Stress: Cardioprotection Mediated by a Longevity Gene.
M. T. Crow (2004)
Circ. Res. 95, 953-956
   Full Text »    PDF »
MFB-1, an F-box-type ubiquitin ligase, regulates TGF-{beta} signalling.
Y. Aoyama, S. Urushiyama, M. Yamada, C. Kato, H. Ide, S. Higuchi, T. Akiyama, and H. Shibuya (2004)
Genes Cells 9, 1093-1101
   Abstract »    Full Text »    PDF »
Shared Transcriptional Signature in Caenorhabditis elegans Dauer Larvae and Long-lived daf-2 Mutants Implicates Detoxification System in Longevity Assurance.
J. J. McElwee, E. Schuster, E. Blanc, J. H. Thomas, and D. Gems (2004)
J. Biol. Chem. 279, 44533-44543
   Abstract »    Full Text »    PDF »
Decreased Lifespan in the Absence of Expression of the Mitochondrial Small Heat Shock Protein Hsp22 in Drosophila.
G. Morrow, S. Battistini, P. Zhang, and R. M. Tanguay (2004)
J. Biol. Chem. 279, 43382-43385
   Abstract »    Full Text »    PDF »
Alternative Polyadenylation Results in a Truncated daf-4 BMP Receptor That Antagonizes DAF-7-mediated Development in Caenorhabditis elegans.
C. V. Gunther and D. L. Riddle (2004)
J. Biol. Chem. 279, 39555-39564
   Abstract »    Full Text »    PDF »
Mate Searching in Caenorhabditis elegans: A Genetic Model for Sex Drive in a Simple Invertebrate.
J. Lipton, G. Kleemann, R. Ghosh, R. Lints, and S. W. Emmons (2004)
J. Neurosci. 24, 7427-7434
   Abstract »    Full Text »    PDF »
The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span.
K. Jia, D. Chen, and D. L. Riddle (2004)
Development 131, 3897-3906
   Abstract »    Full Text »    PDF »
Global gene expression analysis identifies molecular pathways distinguishing blastocyst dormancy and activation.
T. Hamatani, T. Daikoku, H. Wang, H. Matsumoto, M. G. Carter, M. S. H. Ko, and S. K. Dey (2004)
PNAS 101, 10326-10331
   Abstract »    Full Text »    PDF »
The Future of Aging Interventions: Current Status of Efforts to Measure and Modulate the Biological Rate of Aging.
H. R. Warner (2004)
J. Gerontol. A Biol. Sci. Med. Sci. 59, B692-B696
   Abstract »    Full Text »    PDF »
Inside Insulin Signaling, Communication Is Key to Long Life.
A. Antebi (2004)
Sci. Aging Knowl. Environ. 2004, pe25
   Abstract »    Full Text »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)