Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 26 November 1999:
Vol. 286. no. 5445, pp. 1735 - 1738
DOI: 10.1126/science.286.5445.1735
Prev | Table of Contents | Next

Reports

Proapoptotic Bcl-2 Relative Bim Required for Certain Apoptotic Responses, Leukocyte Homeostasis, and to Preclude Autoimmunity

Philippe Bouillet, Donald Metcalf, David C. S. Huang, David M. Tarlinton, Tom W. H. Kay, Frank Köntgen, Jerry M. Adams, *dagger Andreas Strasser *dagger

Apoptosis can be triggered by members of the Bcl-2 protein family, such as Bim, that share only the BH3 domain with this family. Gene targeting in mice revealed important physiological roles for Bim. Lymphoid and myeloid cells accumulated, T cell development was perturbed, and most older mice accumulated plasma cells and succumbed to autoimmune kidney disease. Lymphocytes were refractory to apoptotic stimuli such as cytokine deprivation, calcium ion flux, and microtubule perturbation but not to others. Thus, Bim is required for hematopoietic homeostasis and as a barrier to autoimmunity. Moreover, particular death stimuli appear to activate apoptosis through distinct BH3-only proteins.

The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia.
*   These authors share senior authorship.

dagger    To whom correspondence should be addressed. E-mail: adams{at}wehi.edu.au and strasser{at}wehi.edu.au

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Functional Cooperation of the Proapoptotic Bcl2 Family Proteins Bmf and Bim In Vivo.
A. Hubner, J. Cavanagh-Kyros, M. Rincon, R. A. Flavell, and R. J. Davis (2010)
Mol. Cell. Biol. 30, 98-105
   Abstract »    Full Text »    PDF »
Bim-Mediated Apoptosis Is Not Necessary for Thymic Negative Selection to Ubiquitous Self-Antigens.
Q. Hu, A. Sader, J. C. Parkman, and T. A. Baldwin (2009)
J. Immunol. 183, 7761-7767
   Abstract »    Full Text »    PDF »
Leukocyte Elastase Induces Lung Epithelial Apoptosis via a PAR-1-, NF-{kappa}B-, and p53-Dependent Pathway.
T. Suzuki, C. Yamashita, R. L. Zemans, N. Briones, A. Van Linden, and G. P. Downey (2009)
Am. J. Respir. Cell Mol. Biol. 41, 742-755
   Abstract »    Full Text »    PDF »
TRAIL-Deficient Mice Exhibit Delayed Regression of Retinal Neovascularization.
K. E. Hubert, M. H. Davies, A. J. Stempel, T. S. Griffith, and M. R. Powers (2009)
Am. J. Pathol. 175, 2697-2708
   Abstract »    Full Text »    PDF »
Taking Advantage: High-Affinity B Cells in the Germinal Center Have Lower Death Rates, but Similar Rates of Division, Compared to Low-Affinity Cells.
S. M. Anderson, A. Khalil, M. Uduman, U. Hershberg, Y. Louzoun, A. M. Haberman, S. H. Kleinstein, and M. J. Shlomchik (2009)
J. Immunol. 183, 7314-7325
   Abstract »    Full Text »    PDF »
Age-associated increase in lifespan of naive CD4 T cells contributes to T-cell homeostasis but facilitates development of functional defects.
H. Tsukamoto, K. Clise-Dwyer, G. E. Huston, D. K. Duso, A. L. Buck, L. L. Johnson, L. Haynes, and S. L. Swain (2009)
PNAS 106, 18333-18338
   Abstract »    Full Text »    PDF »
Cell Death.
R. S. Hotchkiss, A. Strasser, J. E. McDunn, and P. E. Swanson (2009)
N. Engl. J. Med. 361, 1570-1583
   Full Text »    PDF »
c-Cbl and Cbl-b Act Redundantly to Protect Osteoclasts from Apoptosis and to Displace HDAC6 from {beta}-Tubulin, Stabilizing Microtubules and Podosomes.
E. Purev, L. Neff, W. C. Horne, and R. Baron (2009)
Mol. Biol. Cell 20, 4021-4030
   Abstract »    Full Text »    PDF »
Bcl-2 Modulation to Activate Apoptosis in Prostate Cancer.
K. Bray, H.-Y. Chen, C. M. Karp, M. May, S. Ganesan, V. Karantza-Wadsworth, R. S. DiPaola, and E. White (2009)
Mol. Cancer Res. 7, 1487-1496
   Abstract »    Full Text »    PDF »
The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease.
T. R. Hercus, D. Thomas, M. A. Guthridge, P. G. Ekert, J. King-Scott, M. W. Parker, and A. F. Lopez (2009)
Blood 114, 1289-1298
   Abstract »    Full Text »    PDF »
The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins.
D. Merino, M. Giam, P. D. Hughes, O. M. Siggs, K. Heger, L. A. O'Reilly, J. M. Adams, A. Strasser, E. F. Lee, W. D. Fairlie, et al. (2009)
J. Cell Biol. 186, 355-362
   Abstract »    Full Text »    PDF »
Runx1 Is a Co-activator with FOXO3 to Mediate Transforming Growth Factor {beta} (TGF{beta})-induced Bim Transcription in Hepatic Cells.
G. M. Wildey and P. H. Howe (2009)
J. Biol. Chem. 284, 20227-20239
   Abstract »    Full Text »    PDF »
MEK/ERK-Mediated Phosphorylation of Bim Is Required to Ensure Survival of T and B Lymphocytes during Mitogenic Stimulation.
L. A. O'Reilly, E. A. Kruse, H. Puthalakath, P. N. Kelly, T. Kaufmann, D. C. S. Huang, and A. Strasser (2009)
J. Immunol. 183, 261-269
   Abstract »    Full Text »    PDF »
Mammalian nitrilase 1 homologue Nit1 is a negative regulator in T cells.
H. Zhang, Y.-J. Hou, S.-Y. Han, E. C. Zhang, K. Huebner, and J. Zhang (2009)
Int. Immunol. 21, 691-703
   Abstract »    Full Text »    PDF »
Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim sustains B lymphopoiesis in the absence of IL-7.
N. D. Huntington, V. Labi, A. Cumano, P. Vieira, A. Strasser, A. Villunger, J. P. Di Santo, and N. L. Alves (2009)
Int. Immunol. 21, 715-725
   Abstract »    Full Text »    PDF »
Dendritic Cells Use Endocytic Pathway for Cross-Priming Class Ib MHC-Restricted CD8{alpha}{alpha}+TCR{alpha}{beta}+ T Cells with Regulatory Properties.
T. R. F. Smith, X. Tang, I. Maricic, Z. Garcia, S. Fanchiang, and V. Kumar (2009)
J. Immunol. 182, 6959-6968
   Abstract »    Full Text »    PDF »
Risk of Non-Hodgkin Lymphoma Associated with Germline Variation in Genes that Regulate the Cell Cycle, Apoptosis, and Lymphocyte Development.
L. M. Morton, M. P. Purdue, T. Zheng, S. S. Wang, B. Armstrong, Y. Zhang, I. Menashe, N. Chatterjee, S. Davis, Q. Lan, et al. (2009)
Cancer Epidemiol. Biomarkers Prev. 18, 1259-1270
   Abstract »    Full Text »    PDF »
A tumor suppressor function for caspase-2.
L. H. Ho, R. Taylor, L. Dorstyn, D. Cakouros, P. Bouillet, and S. Kumar (2009)
PNAS 106, 5336-5341
   Abstract »    Full Text »    PDF »
Selective roles for antiapoptotic MCL-1 during granulocyte development and macrophage effector function.
D. A. Steimer, K. Boyd, O. Takeuchi, J. K. Fisher, G. P. Zambetti, and J. T. Opferman (2009)
Blood 113, 2805-2815
   Abstract »    Full Text »    PDF »
BH3-only protein Bim more critical than Puma in tyrosine kinase inhibitor-induced apoptosis of human leukemic cells and transduced hematopoietic progenitors carrying oncogenic FLT3.
A. Nordigarden, M. Kraft, P. Eliasson, V. Labi, E. W.-F. Lam, A. Villunger, and J.-I. Jonsson (2009)
Blood 113, 2302-2311
   Abstract »    Full Text »    PDF »
FOXO3a: a novel player in thyroid carcinogenesis?.
S. Karger, C. Weidinger, K. Krause, S.-Y. Sheu, T. Aigner, O. Gimm, K.-W. Schmid, H. Dralle, and D. Fuhrer (2009)
Endocr. Relat. Cancer 16, 189-199
   Abstract »    Full Text »    PDF »
Transitional B Cells Exhibit a B Cell Receptor-Specific Nuclear Defect in Gene Transcription.
S. F. Andrews and D. J. Rawlings (2009)
J. Immunol. 182, 2868-2878
   Abstract »    Full Text »    PDF »
Autophagy Provides Nutrients but Can Lead to Chop-dependent Induction of Bim to Sensitize Growth Factor-deprived Cells to Apoptosis.
B. J. Altman, J. A. Wofford, Y. Zhao, J. L. Coloff, E. C. Ferguson, H. L. Wieman, A. E. Day, O. Ilkayeva, and J. C. Rathmell (2009)
Mol. Biol. Cell 20, 1180-1191
   Abstract »    Full Text »    PDF »
Glucose Metabolism Attenuates p53 and Puma-dependent Cell Death upon Growth Factor Deprivation.
Y. Zhao, J. L. Coloff, E. C. Ferguson, S. R. Jacobs, K. Cui, and J. C. Rathmell (2008)
J. Biol. Chem. 283, 36344-36353
   Abstract »    Full Text »    PDF »
NF-{kappa}B1 and c-Rel cooperate to promote the survival of TLR4-activated B cells by neutralizing Bim via distinct mechanisms.
A. Banerjee, R. Grumont, R. Gugasyan, C. White, A. Strasser, and S. Gerondakis (2008)
Blood 112, 5063-5073
   Abstract »    Full Text »    PDF »
Enhanced T Cell Apoptosis within Drak2-Deficient Mice Promotes Resistance to Autoimmunity.
S. J. Ramos, J. B. Hernandez, M. Gatzka, and C. M. Walsh (2008)
J. Immunol. 181, 7606-7616
   Abstract »    Full Text »    PDF »
Fas Expression on Antigen-Specific T Cells Has Costimulatory, Helper, and Down-Regulatory Functions In Vivo for Cytotoxic T Cell Responses but Not for T Cell-Dependent B Cell Responses.
I. Puliaeva, R. Puliaev, A. Shustov, M. Haas, and C. S. Via (2008)
J. Immunol. 181, 5912-5929
   Abstract »    Full Text »    PDF »
Novel therapeutic strategy for osteosarcoma targeting osteoclast differentiation, bone-resorbing activity, and apoptosis pathway.
T. Akiyama, C. R. Dass, and P. F.M. Choong (2008)
Mol. Cancer Ther. 7, 3461-3469
   Abstract »    Full Text »    PDF »
Exploring regulatory mechanisms of CD8+ T cell contraction.
M. Prlic and M. J. Bevan (2008)
PNAS 105, 16689-16694
   Abstract »    Full Text »    PDF »
Loss of BH3-only Protein Bim Inhibits Apoptosis of Hemopoietic Cells in the Fetal Liver and Male Germ Cells but Not Neuronal Cells in Bcl-x-deficient Mice.
R. S. Akhtar, B. J. Klocke, A. Strasser, and K. A. Roth (2008)
J. Histochem. Cytochem. 56, 921-927
   Abstract »    Full Text »    PDF »
Oncogenic B-RafV600E Inhibits Apoptosis and Promotes ERK-dependent Inactivation of Bad and Bim.
C. Sheridan, G. Brumatti, and S. J. Martin (2008)
J. Biol. Chem. 283, 22128-22135
   Abstract »    Full Text »    PDF »
Quantitative Regulation of B Cell Division Destiny by Signal Strength.
M. L. Turner, E. D. Hawkins, and P. D. Hodgkin (2008)
J. Immunol. 181, 374-382
   Abstract »    Full Text »    PDF »
The Anti-Apoptotic Bcl-2 Family Member Mcl-1 Promotes T Lymphocyte Survival at Multiple Stages.
I. Dzhagalov, A. Dunkle, and Y.-W. He (2008)
J. Immunol. 181, 521-528
   Abstract »    Full Text »    PDF »
RACK1 and CIS Mediate the Degradation of BimEL in Cancer Cells.
W. Zhang, G. Z. Cheng, J. Gong, U. Hermanto, C. S. Zong, J. Chan, J. Q. Cheng, and L.-H. Wang (2008)
J. Biol. Chem. 283, 16416-16426
   Abstract »    Full Text »    PDF »
The proapoptotic and antimitogenic protein p66SHC acts as a negative regulator of lymphocyte activation and autoimmunity.
F. Finetti, M. Pellegrini, C. Ulivieri, M. T. Savino, E. Paccagnini, C. Ginanneschi, L. Lanfrancone, P. G. Pelicci, and C. T. Baldari (2008)
Blood 111, 5017-5027
   Abstract »    Full Text »    PDF »
Constitutive Production of NF-{kappa}B2 p52 Is Not Tumorigenic but Predisposes Mice to Inflammatory Autoimmune Disease by Repressing Bim Expression.
Z. Wang, B. Zhang, L. Yang, J. Ding, and H.-F. Ding (2008)
J. Biol. Chem. 283, 10698-10706
   Abstract »    Full Text »    PDF »
Multimodal Targeting of the BCL-2 Family in Cancer.
L. D Walensky (2008)
Am. Assoc. Cancer Res. Educ. Book 2008, 349-356
   Abstract »    Full Text »    PDF »
Bcl-2-family proteins and hematologic malignancies: history and future prospects.
J. C. Reed (2008)
Blood 111, 3322-3330
   Abstract »    Full Text »    PDF »
Loss of the BH3-only protein Bmf impairs B cell homeostasis and accelerates {gamma} irradiation-induced thymic lymphoma development.
V. Labi, M. Erlacher, S. Kiessling, C. Manzl, A. Frenzel, L. O'Reilly, A. Strasser, and A. Villunger (2008)
J. Exp. Med. 205, 641-655
   Abstract »    Full Text »    PDF »
Proapoptotic Bcl-2 Family Member Bim Promotes Persistent Infection and Limits Protective Immunity.
S. Reckling, S. Divanovic, C. L. Karp, S. Wojciechowski, Y. Belkaid, and D. Hildeman (2008)
Infect. Immun. 76, 1179-1185
   Abstract »    Full Text »    PDF »
IL-9 and IL-13 Induce Mucous Cell Metaplasia That Is Reduced by IFN-{gamma} in a Bax-Mediated Pathway.
J. Xiang, J. Rir-Sim-Ah, and Y. Tesfaigzi (2008)
Am. J. Respir. Cell Mol. Biol. 38, 310-317
   Abstract »    Full Text »    PDF »
Activation of the JNK pathway promotes phosphorylation and degradation of BimEL--a novel mechanism of chemoresistance in T-cell acute lymphoblastic leukemia.
K. T. Leung, K. K.-H. Li, S. S.-M. Sun, P. K. S. Chan, V. E.-C. Ooi, and L. C.-M. Chiu (2008)
Carcinogenesis 29, 544-551
   Abstract »    Full Text »    PDF »
Cutting Edge: Contributions of Apoptosis and Anergy to Systemic T Cell Tolerance.
L. Barron, B. Knoechel, J. Lohr, and A. K. Abbas (2008)
J. Immunol. 180, 2762-2766
   Abstract »    Full Text »    PDF »
BH3-only protein Puma contributes to death of antigen-specific T cells during shutdown of an immune response to acute viral infection.
S. F. Fischer, G. T. Belz, and A. Strasser (2008)
PNAS 105, 3035-3040
   Abstract »    Full Text »    PDF »
Steady-state dendritic cells expressing cognate antigen terminate memory CD8+ T-cell responses.
T. J. Kenna, R. Thomas, and R. J. Steptoe (2008)
Blood 111, 2091-2100
   Abstract »    Full Text »    PDF »
No requirement for TRAIL in intrathymic negative selection.
E. Cretney, A. P. Uldrich, F. W. McNab, D. I. Godfrey, and M. J. Smyth (2008)
Int. Immunol. 20, 267-276
   Abstract »    Full Text »    PDF »
A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation.
E. F. Lee, P. E. Czabotar, M. F. van Delft, E. M. Michalak, M. J. Boyle, S. N. Willis, H. Puthalakath, P. Bouillet, P. M. Colman, D. C.S. Huang, et al. (2008)
J. Cell Biol. 180, 341-355
   Abstract »    Full Text »    PDF »
Multiple signaling pathways promote B lymphocyte stimulator dependent B-cell growth and survival.
R. T. Woodland, C. J. Fox, M. R. Schmidt, P. S. Hammerman, J. T. Opferman, S. J. Korsmeyer, D. M. Hilbert, and C. B. Thompson (2008)
Blood 111, 750-760
   Abstract »    Full Text »    PDF »
CCL2 Inhibits the Apoptosis Program Induced by Growth Factor Deprivation, Rescuing Functional T Cells.
E. Diaz-Guerra, R. Vernal, M. J. del Prete, A. Silva, and J. A. Garcia-Sanz (2007)
J. Immunol. 179, 7352-7357
   Abstract »    Full Text »    PDF »
Proapoptotic BH3-only protein Bim is essential for developmentally programmed death of germinal center-derived memory B cells and antibody-forming cells.
S. F. Fischer, P. Bouillet, K. O'Donnell, A. Light, D. M. Tarlinton, and A. Strasser (2007)
Blood 110, 3978-3984
   Abstract »    Full Text »    PDF »
Puma Is a Dominant Regulator of Oxidative Stress Induced Bax Activation and Neuronal Apoptosis.
D. Steckley, M. Karajgikar, L. B. Dale, B. Fuerth, P. Swan, C. Drummond-Main, M. O. Poulter, S. S. G. Ferguson, A. Strasser, and S. P. Cregan (2007)
J. Neurosci. 27, 12989-12999
   Abstract »    Full Text »    PDF »
The BH3-only protein Puma plays an essential role in cytokine deprivation induced apoptosis of mast cells.
M. Ekoff, T. Kaufmann, M. Engstrom, N. Motoyama, A. Villunger, J.-I. Jonsson, A. Strasser, and G. Nilsson (2007)
Blood 110, 3209-3217
   Abstract »    Full Text »    PDF »
Bim Expression Indicates the Pathway to Retinal Cell Death in Development and Degeneration.
F. Doonan, M. Donovan, V. Gomez-Vicente, P. Bouillet, and T. G. Cotter (2007)
J. Neurosci. 27, 10887-10894
   Abstract »    Full Text »    PDF »
Inositol 1,3,4,5-tetrakisphosphate controls proapoptotic Bim gene expression and survival in B cells.
Y. Marechal, X. Pesesse, Y. Jia, V. Pouillon, D. Perez-Morga, J. Daniel, S. Izui, P. J. Cullen, O. Leo, H. R. Luo, et al. (2007)
PNAS 104, 13978-13983
   Abstract »    Full Text »    PDF »
Translational Repression of MCL-1 Couples Stress-induced eIF2{alpha} Phosphorylation to Mitochondrial Apoptosis Initiation.
R. M. Fritsch, G. Schneider, D. Saur, M. Scheibel, and R. M. Schmid (2007)
J. Biol. Chem. 282, 22551-22562
   Abstract »    Full Text »    PDF »
Selective Role of NFATc3 in Positive Selection of Thymocytes.
K. Cante-Barrett, M. M. Winslow, and G. R. Crabtree (2007)
J. Immunol. 179, 103-110
   Abstract »    Full Text »    PDF »
Glycogen Synthase Kinase 3{alpha} and 3{beta} Mediate a Glucose-Sensitive Antiapoptotic Signaling Pathway To Stabilize Mcl-1.
Y. Zhao, B. J. Altman, J. L. Coloff, C. E. Herman, S. R. Jacobs, H. L. Wieman, J. A. Wofford, L. N. Dimascio, O. Ilkayeva, A. Kelekar, et al. (2007)
Mol. Cell. Biol. 27, 4328-4339
   Abstract »    Full Text »    PDF »
Hrk/DP5 contributes to the apoptosis of select neuronal populations but is dispensable for haematopoietic cell apoptosis.
L. Coultas, S. Terzano, T. Thomas, A. Voss, K. Reid, E. G. Stanley, C. L. Scott, P. Bouillet, P. Bartlett, J. Ham, et al. (2007)
J. Cell Sci. 120, 2044-2052
   Abstract »    Full Text »    PDF »
Functional Linkage between NOXA and Bim in Mitochondrial Apoptotic Events.
J. Han, L. A. Goldstein, W. Hou, and H. Rabinowich (2007)
J. Biol. Chem. 282, 16223-16231
   Abstract »    Full Text »    PDF »
NRAS mutation causes a human autoimmune lymphoproliferative syndrome.
J. B. Oliveira, N. Bidere, J. E. Niemela, L. Zheng, K. Sakai, C. P. Nix, R. L. Danner, J. Barb, P. J. Munson, J. M. Puck, et al. (2007)
PNAS 104, 8953-8958
   Abstract »    Full Text »    PDF »
Deficiency of Bim in dendritic cells contributes to overactivation of lymphocytes and autoimmunity.
M. Chen, L. Huang, and J. Wang (2007)
Blood 109, 4360-4367
   Abstract »    Full Text »    PDF »
Two molecular pathways initiate mitochondria-dependent dopaminergic neurodegeneration in experimental Parkinson's disease.
C. Perier, J. Bove, D.-C. Wu, B. Dehay, D.-K. Choi, V. Jackson-Lewis, S. Rathke-Hartlieb, P. Bouillet, A. Strasser, J. B. Schulz, et al. (2007)
PNAS 104, 8161-8166
   Abstract »    Full Text »    PDF »
p53 independent induction of PUMA mediates intestinal apoptosis in response to ischaemia-reperfusion.
B. Wu, W. Qiu, P. Wang, H. Yu, T. Cheng, G. P Zambetti, L. Zhang, and J. Yu (2007)
Gut 56, 645-654
   Abstract »    Full Text »    PDF »
Erythropoietin promotes survival of primary human endothelial cells through PI3K-dependent, NF-{kappa}B-independent upregulation of Bcl-xL.
R. Zhande and A. Karsan (2007)
Am J Physiol Heart Circ Physiol 292, H2467-H2474
   Abstract »    Full Text »    PDF »
Granzyme K Directly Processes Bid to Release Cytochrome c and Endonuclease G Leading to Mitochondria-dependent Cell Death.
T. Zhao, H. Zhang, Y. Guo, and Z. Fan (2007)
J. Biol. Chem. 282, 12104-12111
   Abstract »    Full Text »    PDF »
Unrestrained erythroblast development in Nix-/- mice reveals a mechanism for apoptotic modulation of erythropoiesis.
A. Diwan, A. G. Koesters, A. M. Odley, S. Pushkaran, C. P. Baines, B. T. Spike, D. Daria, A. G. Jegga, H. Geiger, B. J. Aronow, et al. (2007)
PNAS 104, 6794-6799
   Abstract »    Full Text »    PDF »
NBK/BIK antagonizes MCL-1 and BCL-XL and activates BAK-mediated apoptosis in response to protein synthesis inhibition.
T. Shimazu, K. Degenhardt, A. Nur-E-Kamal, J. Zhang, T. Yoshida, Y. Zhang, R. Mathew, E. White, and M. Inouye (2007)
Genes & Dev. 21, 929-941
   Abstract »    Full Text »    PDF »
Fc{epsilon}RI Aggregation Promotes Survival of Connective Tissue-Like Mast Cells but Not Mucosal-Like Mast Cells.
M. Ekoff, A. Strasser, and G. Nilsson (2007)
J. Immunol. 178, 4177-4183
   Abstract »    Full Text »    PDF »
A model of immune regulation as a consequence of randomized lymphocyte division and death times.
E. D. Hawkins, M. L. Turner, M. R. Dowling, C. van Gend, and P. D. Hodgkin (2007)
PNAS 104, 5032-5037
   Abstract »    Full Text »    PDF »
Multiple triggers of cell death in sepsis: death receptor and mitochondrial-mediated apoptosis.
K. C. Chang, J. Unsinger, C. G. Davis, S. J. Schwulst, J. T. Muenzer, A. Strasser, and R. S. Hotchkiss (2007)
FASEB J 21, 708-719
   Abstract »    Full Text »    PDF »
Cutting Edge: Bim Is Required for Superantigen-Mediated B Cell Death.
C. S. Goodyear, M. Corr, F. Sugiyama, D. L. Boyle, and G. J. Silverman (2007)
J. Immunol. 178, 2636-2640
   Abstract »    Full Text »    PDF »
CD4+CD25+ T Cell-Dependent Inhibition of Autoimmunity in Transgenic Mice Overexpressing Human Bcl-2 in T Lymphocytes.
J. Gonzalez, E. Tamayo, I. Santiuste, R. Marquina, L. Buelta, M. A. Gonzalez-Gay, S. Izui, M. Lopez-Hoyos, J. Merino, and R. Merino (2007)
J. Immunol. 178, 2778-2786
   Abstract »    Full Text »    PDF »
Loss of Mcl-1 Protein and Inhibition of Electron Transport Chain Together Induce Anoxic Cell Death.
J. K. Brunelle, E. H. Shroff, H. Perlman, A. Strasser, C. T. Moraes, R. A. Flavell, N. N. Danial, B. Keith, C. B. Thompson, and N. S. Chandel (2007)
Mol. Cell. Biol. 27, 1222-1235
   Abstract »    Full Text »    PDF »
Docetaxel-Induced Apoptosis of Human Melanoma Is Mediated by Activation of c-Jun NH2-Terminal Kinase and Inhibited by the Mitogen-Activated Protein Kinase Extracellular Signal-Regulated Kinase 1/2 Pathway.
N. M. Mhaidat, X. D. Zhang, C. C. Jiang, and P. Hersey (2007)
Clin. Cancer Res. 13, 1308-1314
   Abstract »    Full Text »    PDF »
The antiapoptotic protein Mcl-1 is essential for the survival of neutrophils but not macrophages.
I. Dzhagalov, A. St. John, and Y.-W. He (2007)
Blood 109, 1620-1626
   Abstract »    Full Text »    PDF »
Ultraviolet radiation triggers apoptosis of fibroblasts and skin keratinocytes mainly via the BH3-only protein Noxa.
E. Naik, E. M. Michalak, A. Villunger, J. M. Adams, and A. Strasser (2007)
J. Cell Biol. 176, 415-424
   Abstract »    Full Text »    PDF »
Apoptosis Initiated When BH3 Ligands Engage Multiple Bcl-2 Homologs, Not Bax or Bak.
S. N. Willis, J. I. Fletcher, T. Kaufmann, M. F. van Delft, L. Chen, P. E. Czabotar, H. Ierino, E. F. Lee, W. D. Fairlie, P. Bouillet, et al. (2007)
Science 315, 856-859
   Abstract »    Full Text »    PDF »
Structural and Mechanistic Features of Protein O Glycosylation Linked to CD8+ T-Cell Apoptosis.
S. J. Van Dyken, R. S. Green, and J. D. Marth (2007)
Mol. Cell. Biol. 27, 1096-1111
   Abstract »    Full Text »    PDF »
An Inhibitor of the Kinesin Spindle Protein Activates the Intrinsic Apoptotic Pathway Independently of p53 and De Novo Protein Synthesis.
W. Tao, V. J. South, R. E. Diehl, J. P. Davide, L. Sepp-Lorenzino, M. E. Fraley, K. L. Arrington, and R. B. Lobell (2007)
Mol. Cell. Biol. 27, 689-698
   Abstract »    Full Text »    PDF »
Bcl-xl does not have to bind Bax to protect T cells from death.
X. Liu, Y. Zhu, S. Dai, J. White, F. Peyerl, J. W. Kappler, and P. Marrack (2006)
J. Exp. Med. 203, 2953-2961
   Abstract »    Full Text »    PDF »
Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction.
M. Erlacher, V. Labi, C. Manzl, G. Bock, A. Tzankov, G. Hacker, E. Michalak, A. Strasser, and A. Villunger (2006)
J. Exp. Med. 203, 2939-2951
   Abstract »    Full Text »    PDF »
A critical role for TNF receptor-associated factor 1 and Bim down-regulation in CD8 memory T cell survival.
L. Sabbagh, C. C. Srokowski, G. Pulle, L. M. Snell, B. J. Sedgmen, Y. Liu, E. N. Tsitsikov, and T. H. Watts (2006)
PNAS 103, 18703-18708
   Abstract »    Full Text »    PDF »
TLR-dependent Bim phosphorylation in macrophages is mediated by ERK and is connected to proteasomal degradation of the protein.
G. Hacker, K. Suttner, H. Harada, and S. Kirschnek (2006)
Int. Immunol. 18, 1749-1757
   Abstract »    Full Text »    PDF »
Modulation of Pro- and Antiapoptotic Molecules in Double-Positive (CD4+CD8+) Thymocytes following Dexamethasone Treatment.
R. Bianchini, G. Nocentini, L. T. Krausz, K. Fettucciari, S. Coaccioli, S. Ronchetti, and C. Riccardi (2006)
J. Pharmacol. Exp. Ther. 319, 887-897
   Abstract »    Full Text »    PDF »
Loss of pro-apoptotic Bim promotes accumulation of pulmonary T lymphocytes and enhances allergen-induced goblet cell metaplasia.
J. Pierce, J. Rir-Sima-Ah, I. Estrada, J. Wilder, A. Strasser, and Y. Tesfaigzi (2006)
Am J Physiol Lung Cell Mol Physiol 291, L862-L870
   Abstract »    Full Text »    PDF »
Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic.
J. Kuroda, H. Puthalakath, M. S. Cragg, P. N. Kelly, P. Bouillet, D. C. S. Huang, S. Kimura, O. G. Ottmann, B. J. Druker, A. Villunger, et al. (2006)
PNAS 103, 14907-14912
   Abstract »    Full Text »    PDF »
Role of Bim in Regulating CD8+ T-Cell Responses during Chronic Viral Infection..
J. M. Grayson, A. E. Weant, B. C. Holbrook, and D. Hildeman (2006)
J. Virol. 80, 8627-8638
   Abstract »    Full Text »    PDF »
Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma.
P. G. Ekert, A. M. Jabbour, A. Manoharan, J. E. Heraud, J. Yu, M. Pakusch, E. M. Michalak, P. N. Kelly, B. Callus, T. Kiefer, et al. (2006)
Blood 108, 1461-1468
   Abstract »    Full Text »    PDF »
The NF-{kappa}B regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells.
A. Bauer, A. Villunger, V. Labi, S. F. Fischer, A. Strasser, H. Wagner, R. M. Schmid, and G. Hacker (2006)
PNAS 103, 10979-10984
   Abstract »    Full Text »    PDF »
FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal.
H. You, M. Pellegrini, K. Tsuchihara, K. Yamamoto, G. Hacker, M. Erlacher, A. Villunger, and T. W. Mak (2006)
J. Exp. Med. 203, 1657-1663
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)