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Science 12 July 1996:
Vol. 273. no. 5272, pp. 157 - 0
DOI:

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Lymphocytes enter the lymph nodes by moving along high endothelial venules (HEVs) with a rolling motion that can be mediated by the binding of L-selectin on the cell with peripheral node addressin on the HEVs. Diacovo et al. (p. 252) now show that a second mechanism can operate. Activated platelets can bind to lymphocytes and produce rolling motion through the platelets' P-selectin receptor, even for lymphocytes lacking L-selectin. This second pathway may help platelets deliver lymphocytes to areas of chronic inflammation.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)