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Science 19 July 1996:
Vol. 273. no. 5273, pp. 349 - 352
DOI: 10.1126/science.273.5273.349
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Reports

Cytoplasmic Tail-Dependent Localization of CD1b Antigen-Presenting Molecules to MIICs

Masahiko Sugita, Robin M. Jackman, Elly van Donselaar, Samuel M. Behar, Rick A. Rogers, Peter J. Peters, Michael B. Brenner, Steven A. Porcelli *

CD1 proteins have been implicated as antigen-presenting molecules for T cell-mediated immune responses, but their intracellular localization and trafficking remain uncharacterized. CD1b, a member of this family that presents microbial lipid antigens of exogenous origin, was found to localize to endocytic compartments that included the same specialized subset of endosomes in which major histocompatibility complex (MHC) class II molecules are proposed to bind endocytosed antigens. Unlike MHC class II molecules, which traffic to antigen-loading endosomal compartments [MHC class II compartments (MIICs)] primarily as a consequence of their association with the invariant chain, localization of CD1b to these compartments was dependent on a tyrosine-based motif in its own cytoplasmic tail.

M. Sugita, R. M. Jackman, S. M. Behar, M. B. Brenner, S. A. Porcelli, Lymphocyte Biology Section, Division of Rheumatology and Immunology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
E. van Donselaar and P. J. Peters, Department of Cell Biology and Institute of Biomembranes, Faculty of Medicine, University of Utrecht, Utrecht, Netherlands.
R. A. Rogers, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA.
* To whom correspondence should be addressed.


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Mouse CD1-Autoreactive T Cells Have Diverse Patterns of Reactivity to CD1+ Targets.
L. Brossay, S. Tangri, M. Bix, S. Cardell, R. Locksley, and M. Kronenberg (1998)
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CD1.1 Expression by Mouse Antigen-Presenting Cells and Marginal Zone B Cells.
J. H. Roark, S.-H. Park, J. Jayawardena, U. Kavita, M. Shannon, and A. Bendelac (1998)
J. Immunol. 160, 3121-3127
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Tissue-Specific Recognition of Mouse CD1 Molecules.
S.-H. Park, J. H. Roark, and A. Bendelac (1998)
J. Immunol. 160, 3128-3134
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Maturation of Qa-1b Class I Molecules Requires {beta}2-Microglobulin But Is TAP Independent.
P. J. Robinson, P. J. Travers, A. Stackpoole, L. Flaherty, and H. Djaballah (1998)
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Intracellular Pathway for the Generation of Functional MHC Class II Peptide Complexes in Immature Human Dendritic Cells.
C. Saudrais, D. Spehner, H. de la Salle, A. Bohbot, J.-P. Cazenave, B. Goud, D. Hanau, and J. Salamero (1998)
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Natural Ligand of Mouse CD1d1: Cellular Glycosylphosphatidylinositol.
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II. One size fits all: nonclassical MHC molecules fulfill multiple roles in epithelial cell function.
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T. Kawano, J. Cui, Y. Koezuka, I. Toura, Y. Kaneko, K. Motoki, H. Ueno, R. Nakagawa, H. Sato, E. Kondo, et al. (1997)
Science 278, 1626-1629
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Dendritic Cells: Unique Leukocyte Populations Which Control the Primary Immune Response.
D. N.J. Hart (1997)
Blood 90, 3245-3287
   Full Text »    PDF »
Crystal Structure of Mouse CD1: An MHC-Like Fold with a Large Hydrophobic Binding Groove.
Z. Zeng, A. R. Castaño, B. W. Segelke, E. A. Stura, P. A. Peterson, and I. A. Wilson (1997)
Science 277, 339-345
   Abstract »    Full Text »
Requirements for CD1d Recognition by Human Invariant Valpha 24+ CD4-CD8- T Cells.
M. Exley, J. Garcia, S. P. Balk, and S. Porcelli (1997)
J. Exp. Med. 186, 109-120
   Abstract »    Full Text »    PDF »
Organized Endothelial Cell Surface Signal Transduction in Caveolae Distinct from Glycosylphosphatidylinositol-anchored Protein Microdomains.
J. Liu, P. Oh, T. Horner, R. A. Rogers, and J. E. Schnitzer (1997)
J. Biol. Chem. 272, 7211-7222
   Abstract »    Full Text »    PDF »
CD1c molecules broadly survey the endocytic system.
M. Sugita, N. van der Wel, R. A. Rogers, P. J. Peters, and M. B. Brenner (2000)
PNAS 97, 8445-8450
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)