Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 10 July 2009:
Vol. 325. no. 5937, pp. 201 - 204
DOI: 10.1126/science.1173635
Prev | Table of Contents | Next

Reports

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

Ricki J. Colman,1,* Rozalyn M. Anderson,1 Sterling C. Johnson,1,2,3 Erik K. Kastman,2,3 Kristopher J. Kosmatka,2,3 T. Mark Beasley,4 David B. Allison,4 Christina Cruzen,1 Heather A. Simmons,1 Joseph W. Kemnitz,1,2,5 Richard Weindruch1,2,3,*

Caloric restriction (CR), without malnutrition, delays aging and extends life span in diverse species; however, its effect on resistance to illness and mortality in primates has not been clearly established. We report findings of a 20-year longitudinal adult-onset CR study in rhesus monkeys aimed at filling this critical gap in aging research. In a population of rhesus macaques maintained at the Wisconsin National Primate Research Center, moderate CR lowered the incidence of aging-related deaths. At the time point reported, 50% of control fed animals survived as compared with 80% of the CR animals. Furthermore, CR delayed the onset of age-associated pathologies. Specifically, CR reduced the incidence of diabetes, cancer, cardiovascular disease, and brain atrophy. These data demonstrate that CR slows aging in a primate species.

1 Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, USA.
2 Department of Medicine, University of Wisconsin, Madison, WI 53706, USA.
3 Geriatric Research, Education, and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA.
4 Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
5 Department of Physiology, University of Wisconsin, Madison, WI 53706, USA.

* To whom correspondence should be addressed. E-mail: rcolman{at}primate.wisc.edu (R.J.C.); rhweindr{at}wisc.edu (R.W.)

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Rapamycin enhances lifespan: At last, an advantage for transplant recipients?.
E. K. Geissler (2009)
Nephrol. Dial. Transplant. 24, 3623-3625
   Full Text »    PDF »
Two-Year Body Composition Analyses of Long-Lived GHR Null Mice.
D. E. Berryman, E. O. List, A. J. Palmer, M.-Y. Chung, J. Wright-Piekarski, E. Lubbers, P. O'Connor, S. Okada, and J. J. Kopchick (2009)
J Gerontol A Biol Sci Med Sci
   Abstract »    Full Text »    PDF »
Cancer Risk From Extreme Stressors: Lessons From European Jewish Survivors of World War II.
S. D. Hursting and M. R. Forman (2009)
J Natl Cancer Inst 101, 1436-1437
   Full Text »    PDF »
Water- and nutrient-dependent effects of dietary restriction on Drosophila lifespan.
W. W. Ja, G. B. Carvalho, B. M. Zid, E. M. Mak, T. Brummel, and S. Benzer (2009)
PNAS 106, 18633-18637
   Abstract »    Full Text »    PDF »
Nutrition, Brain Aging, and Neurodegeneration.
J. Joseph, G. Cole, E. Head, and D. Ingram (2009)
J. Neurosci. 29, 12795-12801
   Abstract »    Full Text »    PDF »
DNA Damage, Aging, and Cancer.
J. H.J. Hoeijmakers (2009)
N. Engl. J. Med. 361, 1475-1485
   Full Text »    PDF »
Aging Is RSKy Business.
M. Kaeberlein and P. Kapahi (2009)
Science 326, 55-56
   Abstract »    Full Text »    PDF »
Monkeys' Life Span Extended by Caloric Restriction.
(2009)
Journal Watch (General) 2009, 4
   Full Text »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)