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Science 12 July 1996:
Vol. 273. no. 5272, pp. 157 - 0
DOI:

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This Week in Science

The century-old observation that intercurrent measles infection depresses cell-mediated immunity to other infectious agents may at last be explained. The receptor for the measles virus on the surface of human monocytic cells is a molecule known as CD46. Karp et al. (p. 228) show that the cross-linking of CD46 by infecting virus particles (productive infection by the virus is not required) down-regulates the production of the cytokine interleukin-12. Because interleukin-12 is critical for the development of the cell-mediated response, the host is left vulnerable to infection by intracellular pathogens




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Science. ISSN 0036-8075 (print), 1095-9203 (online)