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Science 12 July 1996:
Vol. 273. no. 5272, pp. 157 - 0
DOI:

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All blood cells start life as hematopoietic stem cells (HSCs), and these critical progenitor cells have been characterized as those carrying the CD34 marker. However, when Osawa et al. (p. 242) used a monoclonal antibody to the mouse analog of CD34 to purify mouse HSCs, the primitive adult bone marrow HSCs were in the none-to-low fraction for this marker. Such cells were used to temporarily reconstitute the immune system of lethally irradiated mice. These results suggest that CD34 may not be an exclusive marker for HSCs.




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