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Special News Report
Infectious proteins--once a biological heresy--have been blamed for mad cows and dead people, and there's plenty of supporting evidence. Still, nobody's proven that prions actually exist or cause disease. In this Special Report, Science takes an in-depth look at the prion hypothesis and the experiments that have convinced many scientists that a protein can turn bad, convert a fellow protein to its cause, and kill a brain cell; they have also convinced many that one prion researcher is worthy of a Nobel Prize. We also examine the work that has led other scientists to dispute these claims, to argue that a virus is responsible for these diseases, and to charge that prion advocates are carrying out science by public relations.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)
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