Lymphocyte migrating through a 3-micrometer pore of a filter (green) and making close contact with a monolayer of cultured human intestinal cells (blue). Culturing of these intestinal epithelial cells with Peyer's patch lymphocytes led to the differentiation of the cell monolayer into M cells, specialized cells that transport particles and bacteria from the interior of the gut to the lymphoid tissue. See page 949 and the related Perspective on page 910. [Image: G. Fischer and L. Lafitte]

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