COVER Simulation of a vesicle interacting with a lipid bilayer (lipid head groups in green and blue, tails in cyan; water is not shown). The computation uses a coarse-grained model with over 1 million interaction sites, equivalent to more than 10 million atoms. See the special section beginning on page 783. Image: Wataru Shinoda/Research Institute for Computational Sciences, National Institute of Advanced Industrial Science and Technology, Japan; Mike Klein/Center for Molecular Modeling, University of Pennsylvania

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